Comparison of Bacteriological, Genetic and Pathological Characters between Escherichia coli O115a,c:K(B) and Citrobacter rodentium

Akiko OKUTANI; Toru TOBE; Chihiro SASAKAWA; Ryoko NOZU; Kazuo GOTOH; Akira TAKAKURA; Toshio ITOH; Yukiko MIYAMOTO; Kikuji ITOH

doi:10.1538/expanim.50.183

Note

Comparison of Bacteriological, Genetic and Pathological Characters between Escherichia coli O115a,c:K(B) and Citrobacter rodentium

Akiko OKUTANI, Toru TOBE, Chihiro SASAKAWA, Ryoko NOZU, Kazuo GOTOH, Akira TAKAKURA, Toshio ITOH, Yukiko MIYAMOTO, Kikuji ITOH

著者情報

Akiko OKUTANI
Laboratory of Veterinary Public Health, Graduate School of Agriculture and Life Sciences, The University of Tokyo
Toru TOBE
Department of Bacterial Infection, Institute of Medical Science, The University of Tokyo
Chihiro SASAKAWA
Department of Bacterial Infection, Institute of Medical Science, The University of Tokyo
Ryoko NOZU
Central Institute for Experimental Animals
Kazuo GOTOH
Central Institute for Experimental Animals
Akira TAKAKURA
Central Institute for Experimental Animals
Toshio ITOH
Central Institute for Experimental Animals
Yukiko MIYAMOTO
Yakult Central Institute for Microbiological Research
Kikuji ITOH
Laboratory of Veterinary Public Health, Graduate School of Agriculture and Life Sciences, The University of Tokyo

キーワード: Citrobacter rodentium, megaenteron, mouse pathogenic Echerichia coli O115a,c:K(B)

ジャーナルフリー

2001 年 50 巻 2 号 p. 183-186

DOI https://doi.org/10.1538/expanim.50.183

詳細

抄録

Murine pathogenic Escherichia coli O115a,c:K(B) (MPEC) is the causative agent of mouse megaenteron, the pathology of which resembles that of transmissible murine colonic hyperplasia caused by Citrobacter rodentium. We compared their genetic and pathological features to reveal the relationship between these two bacteria. To evaluate the genetic distances, 16S rDNA genes were sequenced and biochemical reactions were tested. Mouse strain susceptibility tests, using CF1 MPEC-susceptible germfree mice and BALB/cA(Jic) resistant mice were performed. MPEC strains and C. rodentium showed more than 99.6% identity by comparison of 16S rDNA gene sequences. All results from biochemical reactions and the mouse strain susceptibility tests were identical. It is proposed that MPEC should be reclassified as C. rodentium.

責任著者(Corresponding author)

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