FUKUSHIMA JOURNAL OF MEDICAL SCIENCE
Online ISSN : 2185-4610
Print ISSN : 0016-2590
ISSN-L : 0016-2590
Original Articles
A COMPARISON OF PAIN-RELATED BEHAVIOR FOLLOWING LOCAL APPLICATION OF NUCLEUS PULPOSUS AND/OR MECHANICAL COMPRESSION ON THE DORSAL ROOT GANGLION
NOBUHISA SASAKIMIHO SEKIGUCHIHIROAKI SHISHIDOSHIN-ICHI KIKUCHISHOJI YABUKISHIN-ICHI KONNO
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JOURNAL OPEN ACCESS

2011 Volume 57 Issue 2 Pages 46-53

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Abstract

Symptomatic induction of disc herniation involves both mechanical compression and chemical factors. Inhibitors of tumor necrosis factor-alpha (TNF-α) are known to reduce pain-related behavior in experimental models. Animals were divided into mechanical compression (MC) group; a stainless steel rod was inserted on the dorsal root ganglion, nucleus pulposus (NP) group: NP was harvested from the coccygeal vertebral disc, MC and NP group; rats were received stainless rod and NP, and sham group; rats were received neither rod nor NP. Rats in the MC group received a TNF-α antibody (10 mg/kg) (antibody group) or were not treatment (untreated group). The withdrawal thresholds of the MC, NP and MC+NP groups decreased significantly compared with the sham group. In the antibody group, the threshold was significantly higher than that of the untreated group.
An anti-TNF-α antibody reduced allodynia caused by DRG compression.

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© 2011 The Fukushima Society of Medical Science

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