Attempting to define sentinel node micrometastasis in oral squamous cell carcinoma

Takashi Matsuzuka; Hirokazu Uemura; Seiichi Yoshimoto; Kouki Miura; Akihiro Shiotani; Masashi Sugasawa; Akihiro Homma; Junkichi Yokoyama; Kiyoaki Tsukahara; Tomokazu Yoshizaki; Yasushi Yatabe; Takehiro Kobari; Shigeru Kosuda; Shigeyuki Murono; Yasuhisa Hasegawa

doi:10.5387/fms.2020-17

This article has now been updated. Please use the final version.

Attempting to define sentinel node micrometastasis in oral squamous cell carcinoma

Takashi Matsuzuka, Hirokazu Uemura, Seiichi Yoshimoto, Kouki Miura, Akihiro Shiotani, Masashi Sugasawa, Akihiro Homma, Junkichi Yokoyama, Kiyoaki Tsukahara, Tomokazu Yoshizaki, Yasushi Yatabe, Takehiro Kobari, Shigeru Kosuda, Shigeyuki Murono, Yasuhisa Hasegawa

Author information

Takashi Matsuzuka
Department of Head and Neck Surgery and Otolaryngology, Asahi University Hospital
Radiation Medical Science Center for Fukushima Health Management Survey, Fukushima Medical University
Hirokazu Uemura
Department of Otolaryngology-Head and Neck Surgery, Nara Medical University
Seiichi Yoshimoto
Department of Head and Neck Surgery, National Cancer Center Hospital
Kouki Miura
Department of Head and Neck Oncology and Surgery, International University of Health and Welfare, Mita Hospital
Akihiro Shiotani
Department of Otolaryngology-Head and Neck Surgery, National Defense Medical College
Masashi Sugasawa
Department of Head and Neck Surgery, Saitama Medical University International Medical Center
Akihiro Homma
Department of Otolaryngology, Head and Neck Surgery, Hokkaido University Graduate School of Medicine
Junkichi Yokoyama
Department of Otolaryngology, Head and Neck Surgery, Moriyama Memorial Hospital
Kiyoaki Tsukahara
Department of Otolaryngology-Head and Neck Surgery, Tokyo Medical University Hospital
Tomokazu Yoshizaki
Division of Otolaryngology, Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University
Yasushi Yatabe
Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital
Takehiro Kobari
Department of Otolaryngology, Head and Neck Surgery, Fukushima Medical University
Shigeru Kosuda
Health Care Center, Kouseikai Hospital
Shigeyuki Murono
Department of Otolaryngology, Head and Neck Surgery, Fukushima Medical University
Yasuhisa Hasegawa
Department of Head and Neck Surgery and Otolaryngology, Asahi University Hospital
Department of Head and Surgery, Aichi Cancer Center Hospital

Keywords: sentinel node, oral squamous cell carcinoma, micrometastasis

JOURNAL OPEN ACCESS FULL-TEXT HTML Advance online publication

Article ID: 2020-17

DOI https://doi.org/10.5387/fms.2020-17

The final version of this article is now available: Vol. 66 (2020), No. 3 pp. 143-147

Details

Abstract

OBJECTIVE:The aim of this supplemental study of a sentinel node (SN) biopsy (SNB) trial for oral squamous cell carcinoma (OSCC) was to assess the effectiveness in identifying micrometastasis and determining whether elective neck dissection (END) is necessary.

MATERIALS AND METHODS:Twenty-three patients with pathologically positive SNs were included. The sizes of the metastatic lesions in positive SNs (SMSNs) were classified and the rates of occult metastasis of non-SNs were compared.

RESULTS:The patients were divided according to the SMSN:<0.2 mm (group A, n=3);0.2 mm to <2.0 mm (group B, n=7);and ≥2.0 mm (group C, n=13). The rates of occult metastasis in groups A, B, and C were 0% (0/3), 14% (1/7) and 23% (3/13), respectively.

CONCLUSION:Rare cancer cell distribution to nodes other than SNs was observed in the patients with SN metastatic lesions of at least smaller than 0.2 mm in size, suggesting the possibility of defining SN micrometastasis in N0 OSCC.

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