Old C57BL/6J mice showed poorer retention of passive avoidance task (PAT) than young-adult mice (6-month-old). Subcutaneous injection of dehydroepiandrosterone sulfate (DHEAS) and pregnenolone sulfate (PS) improved the impaired memory retention of PAT in old mice. DHEAS and PS, major neurosteroids that decreases in blood serum with age, may be of use in treatment of neurodegenerative and memory disorders.
