日本薬理学雑誌
Online ISSN : 1347-8397
Print ISSN : 0015-5691
ISSN-L : 0015-5691
気道過敏性発症におけるサイトカインとアラキドン酸代謝産物の役割
気管支喘息と気道過敏性の発症機序―薬理学的展開―
永井 博弌田中 宏幸
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1998 年 111 巻 4 号 p. 233-241

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Bronchial asthma is considered to be a chronic airway inflammatory disease influenced by genetics and environmental factors. Airway hyperresponsiveness (AHR) is a characteristic of the disease generally associated with airway inflammation. Recently, the potential targets for therapeutic intervention in AHR has focused on the inhibition or antagonism of lipid mediators including leukotrienes, thromboxanes and platelet-activating factor. Furthermore, the inhibition of Th2 cytokines, such as interleukin-4 or interleukin-5, is another target for the prevention of AHR. In the present review, we describe the role of cytokines and arachidonic acid metabolites in the onset and development of AHR.

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