諸種脂肪酸並びに鹽類の腎ガス代謝, 腎流血量及び利尿に及ぼす影響

抄録

Simultaneous studies of the gaseous exchange of the kidney, of renal blood flow, and of urinary output during the diuresis induced by intravenous injection of isotonic solution of several fatty acids, and some salts have been carried out on normal, urethanized rabbits which had been operated on by the technique of Barcroft and Brodie. The rate of blood flow through the kidney has been measured directly by a, new electrographic method. The results obtained may be summed up as follows. (1) The average renal oxygen consumption of 108 rabbits in the resting period was calculated as 0.0574 cc ± 0.0043 cc per g of kidney per min. (confidence limits, α = 0.05). By the injection of sodium chloride there was no significant change in oxygen consumption. of the kidney. In the diuresis of potassium chloride, potassium acetate or calcium chloride the oxygen consumption was increased, but contrarily in that of sodium bicarbonate, sodium carbonate or sodium acetate it was decreased. In cases of n/100-fatty acids no significant change in the oxygen consumption was found, but in cases of n/60-and n/30-fatty acids the decrease of oxygen consumption was observed. The decrease of oxygen consumption by the injection of each fatty acid was remarkable in cases Of acetic acid, and then in succession succinic acid and adipic acid, but in cases of suberic acid there was no significant decrease of the oxygen consumption. (2) The average renal carbonic acid formation of 52 rabbits in the resting period was calculated as 0.0811 cc ± 0.0104 cc per g of kidney per min.. And respiratory quotient in the kidney varied from 0.22 to 2.68 (rejection limits, α=0.05). By the injection of n/30-fatty acids the decrease of the carbonic acid formation and the respiratory quotient was occasioned. (3) The average renal blood flow of 108 rabbits in the resting period was calculated as 2.14 cc ± 0.19 cc per g of kidney per min.. By the injection of sodium salts the renal blood flaw decreased, but by that of potassium salts no significant changes of the blood flow were found. On the contrary, by injecting of calcium chloride the blood flow was increased. Fatty acid employed by author had no significant effects to the blood flow. (4) There was a remarkable increase of urinary output in cases of calcium chloride among the salts diuresis and suberic acid among the fatty acids diuresis. (5) The relation between renal blood flow and renal oxygen consumption, and that between renal blood flow and urinary output were concluded to run parallel in their variations. But no relation between. urinary output and renal oxygen consumption could be found.