日本薬理学雑誌
Online ISSN : 1347-8397
Print ISSN : 0015-5691
ISSN-L : 0015-5691
蛙胃内に投与せるDigitalis剤の吸牧に及ぼす界面活性剤の影響
中野 與八郎
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ジャーナル フリー

1953 年 49 巻 1 号 p. 1-10

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The experiment was carried out to study how effective the surface active agents for absorption of g-strophanthin and digitoxin administered in the stomach of a frog. The drug absorption from the alimentary tracts was estimated by measuring the time required for the cardiac arrest from the drug administration. The results obtained were as follows: (1) The absorption of g-strophanthin was promoted by Tween 80 and Tween 20 in concentrations under 0.05%, but was inhibited in the higher. (2) Saponin solution (below 0.1%) promoted the absorption of g-strophanthin. The heart was injured by saponin in a higher concentration, so that it was very difficult to judge the effect of saponin for the drug absorption. (3) Emulgen 408 (polyoxyethylen oleylether) and Aerosol IB prolonged the time to the cardiae arrest by g-strophanthin. (4) The absorption of g-stropanthin applied hypodermically was checked by adding Tween 80, Aerosol IB, and Saponin. (5) The absorption of digitoxin given gastrically was also checked by Tween 80 and Emulgen 408. Thus, the effect of Tween 80 to absorption of g-strophanthin by alimentary tracts differs from that of of digitoxin. It seems to be related with the fact that the former is not easily absorbed but latter is absorbed almost 100%. (6) The micellation phenomenon by Tween 80 (Tween 20) plays a role in the mechanism of the absorption of strophanthin, because the critical concentration promoting the drug absorption coincided with the critical micellation concentration (CMC).

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