Studies on the synthetic anticonvulsants

(1) Pharmacological properties of 3-(2'-methylphenoxy) -propane-1, 2-diol (Myanesin) and 3-(2'-methoxyphenoxy) -propane-1, 2-diol

Abstract

The muscle-relaxing potency and anticonvulsant activity against the convulsions induced by strychnine, picrotoxin and metrazol were conparatively studied with 3- (2'-methylphenoxy) -propane-1, 2-dial (Myanesin) and 3- (2'-methoxyphenoxy) -propane-1, 2diol (Hustosil) in white mice. Result : Against strychnine revealed Myanesin the most powerful anticonvulsant activity, while, Hustosil did against metrazol convulsion. As to the anti. convulsant activity against picrotoxin both of these drugs was relatively weak and just resembled in its degree each other.