錐體外路系の機能に關する藥理學的研究

第1篇 錐體外路毒の作用發現に對する線状體の意義

抄録

Prof. Hara has previously suggested on the two distinguished divisions in the extrapyramidal system, namely the bulbocapnine-reacting system and the harmine-reacting system. In his idea some experiments were carried out in order to explain the significance of striatum for the development of action of extrapyramidal poisons. The corpus striatum of a mouse was divided into six portions by means of the high frequency electrocautery. In determining the effect of harmine and bulbocapnine under these conditions, it was proved that the action of harmine was remarkably decreased when the anterior portion of striatum was injured, and that the injury of the posterior portion exerted a great reduction of action of bulbocapnine.