胎生期の藥理學的研究
ヨードナトリウム (NaI) の鶏胎仔一般發育に及ぼす影響とヨードの吸収並びに排泄に就て
1955 年 51 巻 2 号 p. 173-189_2,en14
詳細
1955 年 51 巻 2 号 p. 173-189_2,en14
A slight inhibition in the development of chick embryo was noted with the injection of NaI solution into developing hens' eggs, especially with the injection of highly concentrated solution. No malformation in the embryo was recorded, and the eggs hatched perfectly with the exceptions in the cases with 20 mg and 30 mg of NaI. The excretion of iodine into the allantoic fluid was found extremely poor, showing the highest value on the 12th day of incubation. The highest rate of excretion was 17.29% recorded in the case received the injection of 10 mg of NaI. In the cases with the injection of 5 mg of NaI, the contents of iodine in the brain, heart and liver were found increased by the above order compared with the untreated control cases, and the weight of each of the above organs were also found increased. As to the histological findings of the liver, regressive degenerations such as vacuolar degeneration, fatty degenerations and necrosis of the hepatic cells were recognized in the cases treated with NaI exceeding 1 mg.
