Abstract
1) Toxicological studies of coriamyrtin were performed on mice and frogs. The characteristic symptoms were the clonic and tetanic convulsion similar to those of picrotoxin. 2) No significant effects were observed on the frog heart in situ, sino-auricular preparation of toad, auricular muscle strip, intestine, uterus and ear vein, latter four of which had been isolated from rabbits. Likewise, there was no special result with regard to the oxygen consumption of rabbit brain slices. 3) With the intravenous injections of 0.1 to 0.2mg/kg, the carotid blood pressure. of rabbit was raised markedly and kept at this level for about 15 to 20 min., while in the range of those doses, convulsion was not observed, and neither vagotomy nor atropinization modified the rise of blood pressure. 4) The pressor action of coriamyrtin was prevented by the previous administration of synaptolytics as well as adrenolytics. 5) Similar effects were also observed on the blood pressure of cat ; but in the spinal cat, neither a rise of blood pressure nor a typical convulsion were observed.
