平滑筋收縮藥の濃度作用曲線に及ぼす温度, pH, 二, 三無機イオンの影響

兎摘出小腸に於ける實驗

抄録

The C-A curves of acetylcholine, pilocarpine and BaCl₂ suited best with the formula Kxⁿ = y/y _max-y (x : drug conc., y : intensity of action measured by tonus rise, y_max : maximum action, K, n : constants) among other formulae under the experimental condition : ordinary Locke-solution of pH 7.2-7.4 used as the bathing fluid at 30°C. The change of temperature (10°-30°C) and of pH (5.8-8.0) and the increase in K·, Ca^·· and Mg^·· conc. of the fluid, modified the values of K and/or y_max of the above formula in various ways, but not of n. The change of the values of K and y_max usually went in the same direction, but occasionally in the opposite ; in the latter case a crossing of the C-A curves in different experimental conditions was produced in the plot (log x, y).