四塩化炭素(CCl₄)障害白鼠に於ける肝細胞膜機能に及ぼすSodium Taurine N-carbodithioate (TDT)の影響

抄録

The influence of TDT administration in vivo on the changes of two enzymic activities in the liver cell membranes damaged by C Cl₄ was observed. The following results were obtained. 1) In normal rats, TDT had no significant effect on NADH-cytochrome c reductase and ATPase activities in membranes or microsomes. 2) TDT was capable of preventing not only the changes of NADH-cytochrome c reductase and ATPase activities in cell membranes produced by C Cl₄ administration, but also the leakage of NADH-cytochrome c reductase into plasma. 3) TDT did not modify the body temperature in normal rats and that induced by C Cl₄, neither. 4) The mechanism of action of TDT was discussed.