1971 年 67 巻 5-6 号 p. 494-508
Influence of morphine on the fine structure of mitochondria in zona fasciculata in rat adrenal cortices electronmicroscopically were studied.
The results obtained are as follows:
Administering morphine in a dose of 20mg/kg to rats, the honeycomlike structures of inner membranes of mitochondria in adrenocortical cells were observed to be altered either tubulo-vesicular or lamellar ones, while the deformed structure gradually became to diminish during repeated administration of the drug.
However, the withdrawal of morphine extensively caused such the deformed changes in the mitochondrial structures again, but in case of the reinjection of the drug, the changes promptly restored to pre-treated structure.