日本薬理学雑誌
Online ISSN : 1347-8397
Print ISSN : 0015-5691
ISSN-L : 0015-5691
Capsaicinの循環器作用知見補遺慢性無線血圧犬における実験
上野 昭
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ジャーナル フリー

1971 年 67 巻 5-6 号 p. 572-579

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In the anesthetized dog, intravenously given capsaicin caused a transient apnoea, bradycardia and hypotension. Blood flows in the mesenteric, renal and femoral arteries were decreased, however, that of of carotid artery was increased even in a small dose causing no changes in the respiration, heart rate and blood pressure. Cardiac muscle contractility was depressed principally whilst capsaicin increased contractility of isolated guinea pig atrium. There were considerable shortening of apnoetic phase and complete vanishment of bradycardia after vagii cut. On the other hand, capsaicin caused a drastic increase of blood pressure and characteristic behavioral changes in the unanesthetized dog.

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