日本薬理学雑誌
Online ISSN : 1347-8397
Print ISSN : 0015-5691
ISSN-L : 0015-5691
ラットおよびイヌの膵液分泌に対する1-Phenyl-1-hydroxy-n-pentaneの効果
若林 庸夫富宇賀 孝国井 洋一山中 鼎司大郷 利治宮尾 興平
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1971 年 67 巻 5-6 号 p. 637-647

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The effect of 1-phenyl-1-hydroxy-n-pentane (PHP) on the pancreatic secretion was investigated on the urethane anestheized rat and the pentobarbital anesthetized canine.
In rats, the secretory volume of pancreatic juice and the output of protein in it were appearently increased by peroral and intraduodenal administration of PHP (50_??_200mg/kg), but not by perrectal administration (100mg/kg). However, these effects of PHP were not so marked in intraperitoneal (50_??_200mg/kg) or intravenous (5_??_10mg/kg) injection.
While biliary secretion was considerably increased in either route of administration of PHP.
PHP administerd intraduodenaly (25_??_200mg/kg) revealed the stimulatory effects of pancreatic secretion in the canine.

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