日本薬理学雑誌
Online ISSN : 1347-8397
Print ISSN : 0015-5691
ISSN-L : 0015-5691
細胞膜機能に関する研究
第1報CCl4適用に伴う白鼠肝細胞膜のNADH-cytochrome creductase活性の消長について
山本 博之増田 康輔口井 正人早野 泰造
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1972 年 68 巻 2 号 p. 142-152

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NADH-cytochrome c reductase activity of liver cell membrane fraction was remarkably elevated after CCl4 administration and reached a peak in 6hr in female and 12hr in male rats, when separation of cell membrane was not disturbed.
In female rats, microsomal and mitochondrial enzyme activities were not significantly influenced 6hr after CCl4 administration. The isolation procedure was adequate in separating membrane from microsome or mitochondria 6hr after CCl4 administration in female rats.
Elevation of this enzyme activity in cell membrane is considered to be due to specific changes in cell membrane rather than to contamination of mitochondrial or microsomal particles in the course of separation.

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