Experiments were done on calculation results of ED50 of Aspirin and AP-14, as well as the potentiation between Aspirin and AP-14.
Results are as follows:
1. ED50 of AP-14 by writhing method in mice was 32.52mg/kg.
ED50 of AP-14 by pressure stimuli on mouse tail was 7.45mg/kg.
2. ED50 of Aspirin by writhing method in mice was 154.4mg/kg.
ED50 of Aspirin by pressure stimuli on mouse tail was 31.62kg/kg.
3. When 1/2ED50 of AP-14 and Aspirin were administrated at the same time, analgesic effect increasec more than ED50 of AP-14 or Aspirin both by writhing method and pressure stimuli on mouse tail.
