日本薬理学雑誌
Online ISSN : 1347-8397
Print ISSN : 0015-5691
ISSN-L : 0015-5691
Thioctic acidのラットにおける急性,亜急性および慢性毒性
冨家 弘子岩波 黄葵渡辺 信夫熊田 重敦
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1972 年 68 巻 3 号 p. 265-275

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The intravenous, intraperitoneal, subcutaneous and oral acute toxicities of thiotic acid were investigated in Sprague-Dawley rats. The minimal lethal dose of the drug was 150mg/kg after intravenous administration.
One and six months toxicity tests using Sprague-Dawley rats were carried out with subcutaneous doses of 8, 16, 32, 64 and 125mg/kg. In these tests, the minimal lethal dose of thioctic acid was 125mg/kg. This was about one half of its LD50. Abnormal changes related to the drug were not observed in systemic signs, values of laboratory tests and histopathological findings.

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