利尿剤に関する研究(第5報)

利尿剤の正常ラットおよび高血圧自然発症ラットに対する利尿作用の単独並びに併用効果について

抄録

The diuretic effects of hypotensive diuretics in spontaneously hypertensive rats (SHR) were compared to that of normal rats (NR). Furthermore, the combination effect in SHR and NR was studied. The following results were obtained;
(1) SHR had most favorable and stronger sensitivity with hydroflumethiazide (HFT) administration.
(2) SHR had a stronger sensitivity on the potassium sparing effect of triamterene (TAT).
(3) SHR had also strong sensitivity on the diuretic effects of methyclothiazide (MCT), hydrochlorothiazide (HCT), furosemide (Fur) and clorexolone (Clo) which are potent in NR.
(4) In SHR, spironolactone (SPL) showed dose-dependent saluresis which was simultaneously accompanied with kaliuresis.
(5) In SHR, mercaptomerine and aminophylline had no diuretic effect.
(6) In NR, combining MCT, HFT, HCT and acetazolamide (ACT) to TAT, all cases showed synergism.
(7) In SHR, combining MCT, HFT, and HCT to TAT, a more excellent synergism was seen than in NR. Particularly, a combination of TAT and HFT resulted in the highest Na⁺/K⁺ excretion ratio.
(8) In NR, combinig MCT, HFT and HCT to SPL, weak synergism was seen.
(9) Combination MCT to SPL showed little synergism in SHR.
(10) When ACT was combined with TAT or SPL in SHR, the diuretic effect decreased more than in a single administration.