5-Hydroxy-L-tryptophan (L-5HTP) の薬理学的研究
(第1報) 5-HTPの中枢神経系におよぼす影響
1973 年 69 巻 4 号 p. 523-541
詳細
1973 年 69 巻 4 号 p. 523-541
Pharmacological properties of L-5HTP in experimental animals were studied and the following results were obtained: L-5HTP produced a decrease in spontaneous locomotor activity in mice, a potentiation of morphine-induced analgesia in mice, an effect of lowering body temp. in mice and a tendency to induce a drowsy EEG pattern in rabbits. Anticonvulsant, anti-tremor, muscle relaxant effects and a potentiation of pentobarbital-induced aneasthesia were not induced by L-5HTP. On the other hand, L-5HTP antagonized the behavioral changes induced by reserpine, tetrabenazine and p-CPA in some experiments.
