駆虫薬に関する基礎的研究(第21報)

豚回虫に対する1-[2-(dodecyloxy) ethyl] pyrrolidine hydrochloride [DEP] の薬理学的研究

抄録

It has been shown that 1-[2-(dodecyloxy) ethyi] pyrrolidine hydrochloride (DEP) has a strong wormcidal action on Ascaris lumbricoides suum. In this paper, absorption pathways into Ascaris body and the mechanism of wormcidal action were investigated with the following results. It was confirmed that DEP was mainly absorbed from the cuticle of Ascaris body in the form of non-ionic base. DEP (100μg/ml) caused a sustained contraction of Ascaris muscle preparation. This contraction was not blocked by d-tubocurarine or other cholinolytics. DEP caused contraction of Ascaris muscle preparation previously depolarized with high K⁺ solutions or treated with triton X-100. When Ascaris muscle preparation was immersed in a Ca-free solution containing EGTA 2mM for 2hr, DEP did not induce a contraction. DEP did not cause a contraction of the glycerol muscle of Ascaris. These results suggest that DEP induces a contraction triggered by releasing calcium from the sarcoplasmic reticulum.