消化性潰瘍治療剤としての糖類硫酸エステルに関する研究
第1報 澱粉分解産物およびその分子篩分画産物の硫酸エステルの抗ペプシン作用,実験的消化性潰瘍抑制作用ならびに血液凝固阻止作用について
1973 年 69 巻 5 号 p. 689-693
詳細
1973 年 69 巻 5 号 p. 689-693
By the application of α-amylase to starch and through the gel filtration of starch hydrolysates, various starch hydrolysates and its filtrates were prepared. To sulfonate starch and sucrose, in addition to various starch hydrolysates and its gel filtrates described above, various sodium saccharide sulfates were prepared. Studies were carried out on these substances regarding the degree of molecular polymerization and the sulfate contents on antipeptic, antiulcerogenic and anticoagulant activities. It was found that 60_??_80 % of the sodium starch hydrolysate sulfate had the strongest activity on antiulcerogenic property. Both polymerization and sulfate contents played a chief role, being the main activities in the appearance of antipeptic, antiulcerogenic and anticoagulant properties. It is also suggested that there is no relation between antipeptic activity in vitro and antiulcerogenic property.
