Abstract
The tumor-inhibiting effect of polysaccharides prepared from Coriolus versicolor Fries against certain kinds of tumor implanted in mice was examined following i.p., i.v. and s.c. administration. 1) Coriolan given i.v. had a marked inhibiting effect against Sarcoma 180. Almost complete regression of the tumor was observed after five doses of 1.0 mg/kg of coriolan, three administrations a week. 2) Carboxymethylcoriolan was less effective than coriolan against Sarcoma 180. 3) Two fractions (F1 and F2) of mycelia polysaccharides by DEAE-cellulose column chromatography revealed a marked effect against Sarcoma 180. These fractions show promise of being efficacious antitumor agents.
