Dietary Psyllium Protects Immature Rats from Estrogenic Activity of Bisphenol A

Abstract

This study was conducted to determine whether dietary psyllium (PSY) can protect against the estrogenic activity of Bisphenol A (BPA) in a rat uterotrophic bioassay. Fifteen immature female rats were fed a commercial diet (blank diet), a blank diet containing 0.1% BPA (control diet), or a blank diet with 0.1% BPA and 5% PSY (PSY diet) for 6 days. The uterine weight of the control group was significantly higher than of the blank group. The uterine weight and the uterine BPA levels of the PSY group were significantly lower than the control group. Serum BPA concentrations and liver BPA levels of the PSY group tended to decrease compared to the control group. However, BPA excretions in feces were significantly higher in the PSY group than in the control group (p<0.01). These observations indicate that dietary PSY feeding can protect against the estrogenic activity of BPA in rats.