2017 Volume 23 Issue 1 Pages 101-109
To explore the hypolipidemic and hepatoprotective effects of tea seed oil, we administered tea seed oil and olive oil to rats to construct the rat hyperlipidemic model induced by high-fat diet, determined biochemical parameters in blood with biochemical kits and biochemical analyzer, calculated arteriosclerosis index (AI) and liver coefficient (LC), detected pathological changes of the livers by microscope and analyzed statistically significant difference of the parameters among the groups. Results showed that tea seed oil can significantly inhibit the body weight gain of rats induced by the high fat diet, significantly decrease concentration levels of triglyceride, total cholesterol, low density lipoprotein cholesterol and activities of aspartate transaminase, alanine transaminase in serum as well as the values of arteriosclerosis index (AI) and liver coefficient (LC) of the hyperlipidemic rats, significantly increase concentration levels of high density lipoprotein Cholesterol of the hyperlipidemic rats, significantly diminish the accumulation of lipid droplets in liver and abate liver damages of hyperlipidemic rats. Conclusion is that tea seed oil has good hypolipidemic and hepatoprotective effects on hyperlipidemic rats.
