Fundamental Toxicological Sciences
Online ISSN : 2189-115X
ISSN-L : 2189-115X
Toxicomics Report
Identification of transcription factors activated by methylmercury in mouse brain
Min-Soek KimTsutomu TakahashiJin-Yong LeeNobuhiko MiuraMasato AsanumaGi-Wook HwangAkira Naganuma
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2017 Volume 4 Issue 1 Pages 37-39

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Abstract

Methylmercury is a harmful heavy metal that selectively disrupts the central nervous system. To clarify the transcription induction mechanism that operates in the brain in response to methylmercury exposure, we used a protein/DNA binding assay to identify transcription factors activated in the cerebella of mice administered methylmercury. We identified PAX4, PAX6, TCF3 and HMGA1 as transcription factors activated by methylmercury.

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© 2017 The Japanese Society of Toxicology
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