Fundamental Toxicological Sciences
Online ISSN : 2189-115X
ISSN-L : 2189-115X
Letter
Small interfering RNA-mediated knockdown of the transcription factor TCF3 enhances sensitivity to methylmercury in mouse neural stem cells
Tsutomu TakahashiYanjiao WangTakashi ToyamaMin-Seok KimShusuke KugeGi-Wook HwangAkira Naganuma
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JOURNALS FREE ACCESS

2017 Volume 4 Issue 2 Pages 41-43

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Abstract

We have reported that four transcription factors (PAX4, PAX6, TCF3, and HMGA1) were markedly activated in the cerebellum of mice treated with methylmercury. In this study, to clarify the relationship between these transcription factors and methylmercury toxicity, siRNA targeting each of the four transcription factors were introduced individually into C17.2 mouse neural stem cells, and the sensitivity of the cells to methylmercury was investigated. Among the four transcription factors, knockdown of the gene for TCF3 increased the methylmercury sensitivity of C17.2 cells. Therefore, we suggest that TCF3 may have a protective effect against methylmercury toxicity.

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© 2017 The Japanese Society of Toxicology
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