Masahiro SAKAGUCHI, Miyuki TAKAO, Saori ONDA, Miho TSUNO, Takashi HASHIMOTO, Kanji AMEMOTO, Yasuo OHYAMA, Mamoru SHIMADA, Goki GON, Masayoshi NISHIHARA, Kentaro MARUYAMA, Kyouwon LEE, Hiroshi OKA, Takanori KURAMOTO, Kazuhide HIGUCHI, Kiyoshi ASHIDA, ATTITUDES ON THE PREVENTION OF MUCOSAL DAMAGE WHEN PRESCRIBING LOW DOSE ASPIRIN (LDA) / NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAID), AND YEARLY CHANGES IN FREQUENCY IN HEMORRHAGIC LDA / NSAID ULCERS, GASTROENTEROLOGICAL ENDOSCOPY, 2014, Volume 56, Issue 2, Pages 250-259, Released on J-STAGE February 26, 2014, Online ISSN 1884-5738, Print ISSN 0387-1207, https://doi.org/10.11280/gee.56.250, https://www.jstage.jst.go.jp/article/gee/56/2/56_250/_article/-char/en, Abstract: Background and Aims : The prevention of mucosal damage by LDA/NSAID is an important concern for general clinical practitioners. Our purpose was to determine yearly changes in the frequency of hemorrhagic LDA/NSAID ulcers in 562 cases of hemorrhagic gastro-duodenal ulcers and practitioners' attitudes on the prevention of hemorrhagic LDA/NSAIDs ulcers. Methods : We investigated the change in frequency of LDA ulcers and NSAID ulcers among digestive-tract hemorrhagic ulcers encountered between 2000 and 2012. We additionally distributed a questionnaire to determine the attitudes of general clinical practitioners concerning prevention of these hemorrhagic ulcers. Results : In contrast to the number of NSAID ulcers, which has been growing yearly, the number of LDA ulcers has been declining since reaching a peak in 2005. LDA ulcers recently dropped to 4% of hemorrhagic ulcers. Results of our questionnaire showed that when NSAIDs are prescribed, gastro-mucosal protective agents are the most used medicines for hemorrhagic-ulcer prevention with 27.9% of physicians prescribing a proton pump inhibitor (PPI). When LDAs are prescribed, a PPI is the most used medicine with a higher rate of 45.3%. Conclusion : It can be considered that the use of PPIs for preventive treatment of LDA ulcers is steadily becoming more common and digestive-tract hemorrhage due to LDA is decreasing.