Abstract
Macroglobulinemia involving gastrointestinal tract is very rare. We experienced a case of Macroglobulinemia with atypical lymphoid cell infiltration into the stomach and small intestine. This patient was 49-years-old female. Her chief complaints were nausea, vomiting and body weight loss. She was diagnosed as Macroglobulinemia in our hospital in 1981. At that time she had no symptom of disturvance of gastrointestinal tract. In 1985, she complained nausea, vomiting and body weight loss. She received barium meal study of the stomach and small intestine. Barium meal study of the stomach revealed coarse granular mucosa and irregularity of the margine of the folds. Barium meal study of the small intestine revealed stenosis with rough granular elevation. Endoscopic studies revealed that diffuse redness, granular mucosa and erosion located at the upper body to the fornix of the stomach. And stenosis with coarse granular mucosa and converging folds were existed in the small intestine near the Treiz ligament. Biopsy was taken from each part. There were massive infiltration of atypical small lymphocytoid cell. Histological diagnosis was diffuse, medium sized cell typed malignant lymphoma. These lymphocytoid were stained with anti IgM and anti k serum by immunoperoxidase technique (PAP). We report a case of Macroglobulinemia involving the stomach and small intestine.
