Abstract
A 45-year-old male patient visited to our hospital complaining of abdominal pain. On colonoscopy two yellowish-white I sp type submucosal tumors were detected in the cecum and in the ascending colon. Polypectomized tumors were 7×7mm, and 8×7mm in size respectively. The excised specimens microscopically showed a well demarcated tumor in the submucosa. Tumor cells had fine eosinophilic granules in the cytoplasm and small oval hyperchromatic nuclei in H-E staining. PAS staining showed acidophilic granules in the cytoplasm. A detailed immunohistochemical staining revealed that the cells were positive for S-100 protein and neuron specific enolase (NSE). 19 cases of granular cell tumor of the large bowel have been reported in Japan. Only two cases including our case had multiple lesions. Endoscopic excision is recommended for these lesions as first choice of treatment.
