Abstract
We report a case of colonic mucosa-associated-lymphoid-tissue(MALT)lymphomaorganized granular mucosa. A 76-year-old man, an elevated serum level of CEA underwent colonoscopy. Itrevealed a granular lesion with erosions in the cecum and ascending colon, and the biopsyspecimens suggested malignant lymphoma. To confirm the diagnosis, endoscopic mucosalresection was perforrned for this lesion and histological and molecular biological analysisrevealed MALT lymphoma. The classification of colonic MALT lymphoma based on endoscopic observation is notavailable so far. fn cases appearing granular pattern as shown in our case, it xnay be difficult to reach a correct diagnosis by endoscopic examination or even by histological study using the colonic biopsy specimen. Therefore, previous case reports of coionic MALT lymphoma in Japan were reviewed to clarify the morphological features of this disease and we concluded that granular mucosa may be one of the important features of this disease in its early stage.
