2018 Volume 15 Issue 3 Pages 216-220
[Background] Polymyxin B-immobilized fiber column direct hemoperfusion (PMX-DHP) is widely used mainly for the treatment of septic shock from abdominal infections, Recently, PMX-DHP over a period of time longer than the standard 2 hours duration has been performed. However, the usefulness of sustained PMX-DHP has not been clarified. ［Methods］In this study, we retrospectively studied the safety and clinical course of sustained PMX-DHP in abdominal septic shock. PMX-DHP was prolonged when sufficient effect is not recognized in 2 hours. [Results] We performed PMX-DHP for 14.8±8.0 hours in 22 patients. The 28-day survival rate was 72.7％ . The safety of PMX-DHP was evaluated. No severe adverse events, such as bleeding symptoms and hyperkalemia, occurred during prolonged PMX-DHP. Improvement of hemodynamic and pulmonary oxygenation continued beyond 2 hours. However, since this study was single-arm study, the results of obtained so far are controversial. [Conclusion] The present result suggested that sustained PMX-DHP in patients with abdominal septic shock can be performed safely. Further studies including our future prospective study are needed in order to demonstrate the usefulness of sustained PMX-DHP.
