Changes of Plasma Fibrinolysis, Coagulation and Serum Lipids in Patients with Liver Cirrhosis

Abstract

Plasma fibrinolysis, coagulation and serum lipids were determined in patients with liver cirrhosis, who were divided into three groups according to clinical manifestation at the time of blood withdrawal. Euglobulin clot lysis time (ELT) was shorter in three patients groups than in normals. As compared with compensated group, ELT was significantly shorter in the ascites group. ELT in the hemorrhage group with a ruptured esophagial varices was significantly longer than in the ascites group, and the mean values in hemorrhage group were the same as that in normals.
There was a significant decrease in plasma fibrinogen in both groups with ascites and hemorrhage compared with the compensated group. The ascites group showed the lowest values of plasma fibrinogen among three groups. Factor VIII activity in three patients groups was higher than in normal level, and all of the patients showed the activity above 50%. Also there das no difference in the positive percentage of FDP more than 10μg/ml among three groups. Even in hemorrhage group, any patient could not been diagnosed undoubtelly as DIC by coagulation and fibrinolysis abnormality.
Positive correlation was found between plasma fibrinogen and serum triglycerides, so that plasma fibrinogen was decreasing in parallel with serum triglycerides concentration in three groups. It is suggested that the simultaneous decrease of plasma fibrinogen and serum triglycerides appeared as a result of reduced production caused by liver damege.