1978 Volume 15 Issue 3 Pages 245-250
Serum glycosaminoglycans (GAG) were measured by a modified method of Emura et al in 552 persons (male 180, female 372) at the annual health examination in Fukuoka City. Serum GAG concentration of various disease groups was compared with that of healthy group.
1) The mean concentration of GAG in the serum of healthy males (n=50) was 0.80±0.16 and in females (n=108) 0.79±0.16mg per 100ml of serum. There was no significant sex or age variations in serum GAG concentration (Table 2).
2) In the disease groups, significantly high concentration of serum GAG was observed in groups of hypertensive (n=175), atherosclerosis (n=133), hypercholesterolemia (n=87), hyper-beta-lipoproteinemia (n=67), and hyperlipidemia (n=87) (p<0.005∼0.001). Liver disease group showed significantly reduced serum GAG concentration (p<0.001) (Fig. 4).
3) In atherosclerosis-group, serum GAG concentration was compared with serum cholesterol, beta-lipoprotein and total lipid concentrations. There were, however, no significant correlations between these values.