1978 Volume 15 Issue 3 Pages 251-259
In order to estimate“normal values”or“normal ranges”for serum chemical constitutents in the aged subjects, the statistical approaches of consecutive patient data were carried out according to Hoffmann's method. The subjects were classified by sex and age into eight groups, consisting of approximately 1500 patients in each group. The data of medical examinations of the subjects over 65 years old, living in the Tokyo Metropolitan Homes for the Aged, new participants of the Homes and young healthy adults were compared with data of the hospital patients.
The results were as follows:
1. As for electrolytes, there were sex differences in potassium, chloride and inorganic phosphorus and the values of sodium and calcium decreased with aging in both sexes.
2. In the analyses of nonprotein nitrogenous constituents, the mean values of bilirubin, urea nitrogen, creatinine and uric acid in males were significantly higher than those in females. Age was accompanied by increases in estimated normal limits of urea nitrogen and creatinine for both sexes. The present data suggested that a trend towards lower uric acid levels with aging for males, whereas higher for females.
3. There was either no or only a slight difference in serum total protein between sexes. On the other hand, a significant decrease with age and significant differences with groups were observed.
4. As for serum cholesterol level, the present results were in substantial agreement with previously published reports.
5. The present results suggested that there were trends to increase the standard deviations of various chemical constituents with aging, and that the normal values and ranges were valid only for the laboratory testing of the specimens and for the group tested.