Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
Print ISSN : 0300-9173
Effect of Age upon Lipofuscin Deposition in the Human Hepatic Cells of Different Races
Tsuneko SatoHisashi Tauchi
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1979 Volume 16 Issue 4 Pages 329-338


Quantitative analysis of the autofluorescent lipofuscin pigment granules in the human hepatic cells of 87 native male Japanese (21-116 years of age) and 97 U. S. male Caucasian s (22-89 years of age) were made statistically.
Number of hepatic cells with pigment granules and amount of the pigment per hepatic cell are both larger in the central zone than in the peripheral, and they are also generally larger in U. S. Caucasians than in the native Japanese.
The amount of pigment per hepatic cell of the native Japanese increased with age significantly after 70 years of age; in case of the U. S. Caucasians the pigment increased in amount significantly in seventh decade but did not increase thereafter.
Mean value of size of the pigment granules increased with age, especially markedly after 60 years of age in the native Japanese, but in the U. S. Caucasians, it decreased slightly after 60 years of age.
The increase in amount of lipofuscin pigment and decrease in number of hepatic cells were generally noticed with advancement of age, however, no statiscical significant correlation was noted between them.
Although large amount of the lipofuscin pigment was accumulated very frequently in the aged individuals, the pigment deposition was not considered to be an essential change of senility, but seemed to be due to some of metabolic changes, which occur more frequently in the aged.

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