1980 Volume 17 Issue 6 Pages 595-600
An analysis was made of the high density lipoprotein-cholesterol (HDL-CH) levels of 18 patients (5 males, 13 females) suffering from ischemic cerebrovascular disorders (2 suffered transient ischemic attacks) and who had experienced apoplectic strokes. Their HDL-CH levels had been determined several times prior to the strokes.
The HDL-CH levels were determined by the enzyme method (TC-Kit, Nippon Shoji) after centrifugation and precipitation of low density lipoproteins (LDL) and very low density lipoproteins (VLDL) in 4% NaPhT and 2M MgCl2. In some cases, HDL-CH levels were arrived at, through use of a conversion formula, from HDL-phospholipid levels which are directly convertible to HDL-CH levels.
The HDL-CH levels of both males and females determined at more than six months before a stroke were below the normal level (40 to 67mg/dl) in most cases while those within six months were lower still, and there was a tendency to descend to even lower levels immediately (24 hours) after a stroke.
These results suggest that the lowered HDL-CH levels of patients with ischemic cerebrovascular disorders are due to several factors, one such factor being the existence prior to strokes of lowered HDL-CH levels which had contributed to accelerate the development of atherosclerosis, and another the lowered HDL-CH levels appearing several months before or immediately after strokes, indicating a direct correlation between such lowered levels and the occurrence of strokes.