1985 Volume 22 Issue 1 Pages 13-19
Platelet aggregation, circulating Platelet aggregates, β-thromboglobulin (β-TG) of plasma and platelet, plasma lipid, apoprotein, antithrombin III and euglobulin lysis time (ELT) were estimated in 29 diabetic patients (DM group) and 37 nondiabetic patients (AS group) with arteriosclerosis compared to 18 normal subjects (NC group). Platelet aggregation induced by ADP, collagen, adrenaline and arachidonic acid was studied by the turbidometric method and circulating platelet aggregates was studied by the method of Wu and Hoak. β-TG, apoprotein and antithrombin III were measured by radioimmunoassay, immunodiffusion and amidolytic heparin cofactor method, respectively.
The most enhanced platelet aggregation was found in AS group. The level of circulating platelet aggregates in AS and DM group was higher than that in NC group. The level of β-TG of plasma and platelet in DM group was the highest among the 3 groups. The apoprotein A-I and A-II in DM group were the lowest. ELT in DM group was significantly lengthened, but there was no significant difference among the 3 groups.
Theses results indicate that diabetic macroangiopathy is associated with the elevated levels of β-TG and circulating platelet aggregates and the reduced levels of apoprotein A-I and A-II and fibrinolysis and that the abnormal platelet function, blood lipid and fibrinolysis may contribute to the progression of diabetic macroangiopathy.
