An 88-Year-Old Female Case with Hyperalphalipoproteinemia Associated with Deficiency of Cholesteryl-Ester Transfer Activity

Abstract

An 88-year-old female was admitted to our hospital for examination of hyperalphalipoproteinemia. The high level of her serum high-density lipoprotein cholesterol (HDL-C, 148mg/dl) was due to cholesterol amount of HDL₂-C but not HDL₃-C, and serum cholesteryl ester transfer activity (CETA) was at a non-detectable level. Despite her age, apparent atherosclerotic changes were not observed. She may be the oldest case of hyperalphalipoproteinemia, possibly due to deficiency of serum CETA.