Endocrine Hypertension

Abstract

Endocrine Hypertension, is, in a narrow sense, defined as adrenal hypertension, including mainly pheochromocytoma, Cushing's syndrome, a syndrome of primary aldosteronism and it's related minaralocorticoid excess disorders. In memory of a great contribution to hypertensiology by the late Prof. Murakami, who was the first author to write on pheochromocytoma in Japan, this paper is dedicated to reviewing the current status of adrenal hypertension in Japan from the epidemiological viewpoint, putting emphasis upon the clinical characteristics of aged patients with adrenal hypertension. Secondly, some topics in the research field of each adrenal hypertension are briefly introduced. Thirdly, our recent data are presented, showing 11β-hydroxysteroid dehydrogenase (11β-HSD) mRNA expression in resistance vessels and decreased 11β-HSD activities in vessels in SHR which supports the hypothesis that there might exist a subtype identified as partial impairment of 11β-HSD in patients with essential hypertension.