1993 Volume 30 Issue 9 Pages 817-825
The effects of high-purity IPA-E administration on changes in serum lipids and factors that may affect those changes were investigated in 55 patients with arteriosclerotic disease (34 males and 21 females, aged 43-85) under a regular daily diet. Daily administration of 1800mg or 900mg IPA-E resulted in a significant decrease or tendency to decrease in serum TG, TC and LDL-C 4 weeks after the initial administration, which continued throughout the administration period. Apoprotein analysis revealed a significant increase in A-I and a significant decrease in B and E after the administration of IPA-E. Lipoprotein analysis disclosed decreasing tendency of VLDL, IDL, LDL and TG, where the changes in VLDL-C, VLDL-TG and TG were significant. The amount and rate of change in TG, TC and LDL-C after IPA-E administration had a significant negative correlation with their respective pre-administration values. The decrease from pre-administration values was significant for patients with abnormal values in both dosage groups. The average rate of decrease in TC and LDL-C were greater in the group receiving administration of 1800mg/day than that receiving 900mg/day, but the difference in the change was not significant between the 2 groups. Correlations between the amount or rate of decrease in TC or LDL-C and the baseline value, achieved value, or amount or rate of increase in plasma IPA concentration and IPA/AA ratio were not significant. However, the negative correlation between the rate of change in TG and achieved IPA concentration was significant. Factors such as age, gender, presence of diabetes mellitus, or calcium antagonist or diuretic administration did not significantly affect the changes in serum lipids resulting from administration of IPA-E. According to phenotype, the decrease in TG and the increase in LDL-C after IPA-E administration were great and HDL-C increased slightly in type IV hyperlipidemia group. By contrast, LDL-C and HDL-C decreased slightly in type IIa hyperlipidemia group. The changes in type IIb hyperlipidemia group were an intermediate type between the type IV and type IIa hyperlipidemia groups. The changes in serum lipids were minimal in the normolipidemia group.
