Changes of the Plasma Levels of Tissue Plasminogen Activator and Plasminogen Activator Inhibitor-1 in Cerebral Infarction induced by the Venous Occlusion

Abstract

To examine the fibrinolytic system and platelet factors (PF4 and β-TG), we conducted a venous occlusion test (V.O. test) on two groups of elderly patients suffering from cerebral infarction, one group being able to walk (A group), the other being bed-ridden for during a long period (B group). Their levels of t-PA, PAI-1 antigen and platelet factors were compared between A or B, A+B and healthy elderly groups. The t-PA antigen level of both group A and B after the V.O. test tended to increase: The t-PA values of A+B groups after the V.O. test were also similar to that of the healthy elderly. The PAT-1 antigen level of both group A and B before the V.O. test was higher than that of the healthy elderly. However, the PAT-1 antigen level of both group A and B tended to decrease after the V.O. test. No remarkable changes were noted in PF4 and β-TG, which have been thought to reflect platelet function. The above findings suggest that the fibrinolytic activity in A or B groups can recover through stimulation by exercise training and some medical treatment.