Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
Print ISSN : 0300-9173
Role of Impaired Glucose Tolerance in the Progression of Hypertension
Youichi TakagiShigeyuki SaitohShigemichi TanakaKazuaki Shimamoto
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1998 Volume 35 Issue 11 Pages 830-838


The present report describes the relationship between the glucose tolerance and hypertension surveyed in a ten-year longitudinal epidemiological study in two rural communities in Hokkaido, Japan.
The 1972 subjects (928 men and 1044 women, aged 40-64, mean 51.1±7.0 years) were randomly selected in 1977 and 1978, underwent a 50-g oral glucose tolerance test (GTT) at the first year. The prevalences of borderline hypertension (BHT) and of hypertension (HT) were highest in those with diabetes mellitus (DM), followed by those with borderline diabetes (BDM) and those normal glucose tolerance (NGT). Systolic and diastolic blood pressure were significantly and positively correlated with plasma glucose levels during fasting (FPG), 60min, after GTT (60G), and 120min. after GTT (120G), and were ordered as follows: NGT<BDM<DM. The FPG, 60G and 120G plasma glucose levels were all significantly higher in BHT and HT than in NT. The prevalences of the progression to hypertension from non-hypertension over the ten-year follow-up period were ordered as follows: NGT<BDM<DM. Glucose levels in progression group were higher than those in non-progression group. Multiple logistic regression analysis indicated that age, glucose intolerance, systolic blood pressure, and obesity index were significant predictors of the progression to hypertension.
These results indicate that impaired glucose tolerance may be associated with hypertension, and might play a role in the development of hypertension.

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