Clinical Effect of Arotinolol Hydrochloride and its Influence on Renal Function in Elderly Patients with Essential Hypertension

Abstract

Arotinolol hydrochloride with α-and β-receptor blocking action, developed in Japan, is mainly used for the treatment of hypertension. The study population consisted of 42 outpatients with essential hypertension with a blood pressure greater or equal to 160/96mmHg, 10 men and 32 women, with a mean age of 77.5 year. The patients received 10mg arotinolol hydrochloride daily for 24 weeks which was taken orally twice a day. We evaluated the changes of blood pressure, heart rate and chief complaints of patients before and every 4 weeks during treatment and the renal function before, 12 weeks after and 24 weeks after, the administration of arotinolol hydrochloride.
Blood pressure and heart rate decreased significantly after 4 weeks of treatment with arotinolol hydrochloride (p<0.05). However, no significant changes were found in blood urea nitrogen, serum creatinine, serum albumin, β₂-microglobuline, NAG or creatinine clearance during the 24 weeks of treatment. These results indicate that arotinolol hydrochloride has antihypertensive effects without renal dysfunction in elderly patients with essential hypertension.