Molecular mechanism of age-related osteoporosis

Abstract

Bone loss by ageing has been investigated from standpoints of systemic abnormality and some deficiency in osteoblastic bone formation. This seminar summarizes the involvements of a key molecule of adipocytic differentiation PPAR-gamma, essential IGF-I signaling molecules IRS-1 and IRS-2, and an anti-aging gene klotho in the pathophysiology of age-related osteoporosis.