Genes & Genetic Systems
Online ISSN : 1880-5779
Print ISSN : 1341-7568
ISSN-L : 1341-7568
Review
The smooth and stable operation of centromeres
Yuki OgiyamaKojiro Ishii
Author information
JOURNALS OPEN ACCESS FULL-TEXT HTML

2012 Volume 87 Issue 2 Pages 63-73

Details
Abstract

The centromere functions as a unique chromosomal attachment site for microtubules. Appropriate microtubule attachment is fundamental for organized chromosome behavior during mitosis and meiosis. Hence, centromeres must function both smoothly and stably. However, centromeric DNA sequences are poorly conserved between species despite common functions and similar centromeric protein composition, which leads us to the question: how are centromeres established and maintained? In this review, we summarize the recent progress in deciphering the mechanisms of centromere function. Specifically, we focus our attention on mechanisms closely-related to centromeric DNA and chromatin. By gathering such information, we hope to reveal a new dimension to the true nature of centromeres.

Information related to the author
© 2012 by The Genetics Society of Japan
Next article
feedback
Top