Genes & Genetic Systems
Online ISSN : 1880-5779
Print ISSN : 1341-7568
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Genetic dissection of Nucleoporin 160 (Nup160), a gene involved in multiple phenotypes of reproductive isolation in Drosophila
Kazunori MaeharaTakayuki MurataNaoki AoyamaKenji MatsunoKyoichi Sawamura
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Volume 87 (2012) Issue 2 Pages 99-106

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Previous reports have suggested that the Nucleoporin 160 (Nup160) gene of Drosophila simulans (Nup160sim) causes the hybrid inviability, female sterility, and morphological anomalies that are observed in crosses with D. melanogaster. Here we have confirmed this observation by transposon excision from the P{EP}Nup160EP372 insertion mutation of D. melanogaster. Null mutations of the Nup160 gene resulted in the three phenotypes caused by Nup160sim, but revertants of the gene did not. Interestingly, several mutations produced by excision partially complemented hybrid inviability, female sterility, or morphological anomalies. In the future, these mutations will be useful to further our understanding of the developmental mechanisms of reproductive isolation. Based on our analyses with the Nup160sim introgression line, the lethal phase of hybrid inviability was determined to be during the early pupal stage. Our analysis also suggested that homozygous Nup160sim in D. melanogaster leads to slow development. Thus, Nup160sim is involved in multiple aspects of reproductive isolation between these two species.

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© 2012 by The Genetics Society of Japan
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