Advanced age – a critical risk factor for recurrent miscarriage

Hongmei Sun; Youhui Lu; Qing Qi; Meiling Li; Jing Zhou; Jing Wang; Jing Lin; Liwen Cao; Yan Du; Lisha Li; Ling Wang

doi:10.35772/ghm.2023.01066

Letter

Advanced age – a critical risk factor for recurrent miscarriage

Hongmei Sun, Youhui Lu, Qing Qi, Meiling Li, Jing Zhou, Jing Wang, Jing Lin, Liwen Cao, Yan Du, Lisha Li, Ling Wang

Author information

Hongmei Sun
Laboratory for Reproductive Immunology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
The Academy of Integrative Medicine of Fudan University, Shanghai, China.
Shanghai Key Laboratory of Female Reproductive Endocrine-related Diseases, Shanghai, China.
HeXi University, Zhangye, Gansu, China.
Youhui Lu
Laboratory for Reproductive Immunology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
The Academy of Integrative Medicine of Fudan University, Shanghai, China.
Shanghai Key Laboratory of Female Reproductive Endocrine-related Diseases, Shanghai, China.
Qing Qi
Laboratory for Reproductive Immunology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
The Academy of Integrative Medicine of Fudan University, Shanghai, China.
Shanghai Key Laboratory of Female Reproductive Endocrine-related Diseases, Shanghai, China.
Meiling Li
Department of Nosocomial Infection, The International Peace Maternity & Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jing Zhou
Laboratory for Reproductive Immunology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
The Academy of Integrative Medicine of Fudan University, Shanghai, China.
Shanghai Key Laboratory of Female Reproductive Endocrine-related Diseases, Shanghai, China.
Jing Wang
Laboratory for Reproductive Immunology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
The Academy of Integrative Medicine of Fudan University, Shanghai, China.
Shanghai Key Laboratory of Female Reproductive Endocrine-related Diseases, Shanghai, China.
Jing Lin
Laboratory for Reproductive Immunology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
The Academy of Integrative Medicine of Fudan University, Shanghai, China.
Shanghai Key Laboratory of Female Reproductive Endocrine-related Diseases, Shanghai, China.
Liwen Cao
Reproductive Medicine Center of Zhoushan Maternal and Child Health Care Hospital, Zhoushan, Zhejiang, China.
Yan Du
Laboratory for Reproductive Immunology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
The Academy of Integrative Medicine of Fudan University, Shanghai, China.
Office of Clinical Epidemiology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Lisha Li
Laboratory for Reproductive Immunology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
The Academy of Integrative Medicine of Fudan University, Shanghai, China.
Shanghai Key Laboratory of Female Reproductive Endocrine-related Diseases, Shanghai, China.
Ling Wang
Laboratory for Reproductive Immunology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
The Academy of Integrative Medicine of Fudan University, Shanghai, China.
Shanghai Key Laboratory of Female Reproductive Endocrine-related Diseases, Shanghai, China.

Keywords: maternal age, recurrent spontaneous abortion, etiology, outcome of pregnancy

JOURNAL FREE ACCESS

2023 Volume 5 Issue 5 Pages 316-318

DOI https://doi.org/10.35772/ghm.2023.01066

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Details

Abstract

Recurrent spontaneous abortion (RSA) is a multifactorial disease that seriously affects women’s physical and mental health. With the advent of efficient contraception, the trend for women towards later maternity until their thirties or even forties. Nevertheless, the risk of miscarriage is strongly related to maternal age. We performed a retrospective analysis to evaluate the etiology of RSA through age groups. The results demonstrated that intrauterine adhesions and ovarian dysfunction were responsible for increased miscarriages in older RSA patients. In conclusion, older women will bear a higher risk of miscarriage, mainly due to uterine adhesions or decreased ovarian function.

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