Genome Informatics
Online ISSN : 2185-842X
Print ISSN : 0919-9454
ISSN-L : 0919-9454
Systematic Functional Assessment of Human Protein-Protein Interaction Maps
Gautam ChaurasiaHanspeter HerzelErich E. WankerMatthias E. Futschik
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JOURNAL FREE ACCESS

2006 Volume 17 Issue 1 Pages 36-45

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Abstract

Protein-protein interaction maps can contribute substantially to the discovery of protein cooperation patterns in the cell. Recently, several large-scale human protein-protein interaction maps have been generated using experimental or computational approaches. Evaluation of these maps is likely to provide a better understanding of human biology. However, careful analysis is needed, as the comparison of interaction maps of lower eukaryotes showed a surprising divergence between different maps. Here, we present a first systematic functional assessment of eight currently available large-scale human protein-protein interaction maps. The analysis shows that these maps include a large number of common proteins, but only a small number of common interactions. We detected several types of biases that need to be considered in the future utilization of these maps.

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© Japanese Society for Bioinformatics
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